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Selwyn M Vickers Selected Research

triptolide

7/2019Correction: Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
1/2019Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia.
5/2015Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide.
8/2014Sorafenib and triptolide as combination therapy for hepatocellular carcinoma.
6/2014Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway.
6/2014Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells.
11/2013Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1.
9/2013miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death.
4/2013Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor-kappa B activity.
1/2013Minnelide: a novel therapeutic that promotes apoptosis in non-small cell lung carcinoma in vivo.
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Selwyn M Vickers Research Topics

Disease

55Neoplasms (Cancer)
01/2021 - 02/2002
45Pancreatic Neoplasms (Pancreatic Cancer)
01/2022 - 02/2002
19Adenocarcinoma
01/2022 - 07/2002
6Cholangiocarcinoma
06/2011 - 06/2002
5Neoplasm Metastasis (Metastasis)
01/2018 - 09/2007
5Chronic Pancreatitis
07/2014 - 10/2006
3Pain (Aches)
07/2014 - 04/2012
3Neuroblastoma
04/2013 - 08/2009
2Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
09/2019 - 01/2019
2Pancreatitis
07/2014 - 04/2014
2Body Weight (Weight, Body)
07/2014 - 04/2014
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2013 - 04/2007
2Stomach Neoplasms (Stomach Cancer)
01/2011 - 08/2009
2Carcinoma (Carcinomatosis)
07/2007 - 05/2005
2Obesity
11/2005 - 05/2005
1Heart Failure
01/2021
1Disease Progression
01/2021
1Melanoma (Melanoma, Malignant)
01/2018
1Colonic Neoplasms (Colon Cancer)
01/2018
1Hepatocellular Carcinoma (Hepatoma)
08/2014
1Tics (Tic)
05/2014
1Fibrosis (Cirrhosis)
04/2014

Drug/Important Bio-Agent (IBA)

18triptolideIBA
07/2019 - 10/2007
16Proteins (Proteins, Gene)FDA Link
05/2015 - 02/2002
1014-O-phosphonooxymethyltriptolide disodium saltIBA
09/2019 - 10/2012
9DiterpenesIBA
01/2019 - 10/2007
8LigandsIBA
06/2014 - 07/2002
6GemcitabineFDA Link
10/2016 - 05/2003
6Small Interfering RNA (siRNA)IBA
01/2012 - 05/2005
5Pharmaceutical PreparationsIBA
01/2018 - 07/2007
5RNA (Ribonucleic Acid)IBA
10/2016 - 02/2006
5ErbB Receptors (EGF Receptor)IBA
11/2007 - 12/2004
4Death Domain ReceptorsIBA
06/2014 - 11/2006
4Erlotinib Hydrochloride (CP 358,774)FDA Link
11/2007 - 04/2007
3ProdrugsIBA
01/2019 - 11/2013
3InterferonsIBA
05/2015 - 11/2012
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2014 - 02/2010
3Biomarkers (Surrogate Marker)IBA
07/2013 - 10/2006
3Biological ProductsIBA
08/2010 - 07/2002
3Epidermal Growth Factor (EGF)IBA
08/2010 - 05/2003
3Cyclooxygenase 2 (Cyclooxygenase-2)IBA
04/2008 - 10/2003
3tigatuzumabIBA
12/2007 - 11/2006
3Messenger RNA (mRNA)IBA
12/2007 - 02/2002
3TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
12/2007 - 11/2006
3Tyrosine Kinase InhibitorsIBA
07/2007 - 04/2007
2Sp1 Transcription FactorIBA
07/2019 - 11/2013
2DNA (Deoxyribonucleic Acid)IBA
03/2016 - 04/2007
2Peptides (Polypeptides)IBA
10/2015 - 01/2012
2DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
05/2015 - 09/2010
2Interferon-alpha (Interferon Alfa)IBA
05/2015 - 07/2012
2Caspase 3 (Caspase-3)IBA
05/2015 - 02/2010
2Insulin (Novolin)FDA Link
07/2014 - 04/2014
2EnzymesIBA
06/2014 - 02/2002
2Narcotics (Narcotic Analgesics)IBA
04/2014 - 04/2012
2Pain-FreeIBA
04/2014 - 04/2012
2Fluorouracil (Carac)FDA LinkGeneric
02/2014 - 04/2008
2VaccinesIBA
10/2013 - 07/2013
2AntigensIBA
10/2013 - 07/2013
2OvalbuminIBA
10/2013 - 07/2013
2rAd40IBA
10/2013 - 07/2013
2MesothelinIBA
07/2013 - 10/2006
2CaspasesIBA
01/2013 - 08/2010
2HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
05/2009 - 10/2007
2Monoclonal AntibodiesIBA
12/2007 - 11/2006
2Transforming Growth Factor beta (TGF-beta)IBA
05/2005 - 04/2004
2Interferon-gamma (Interferon, gamma)IBA
04/2005 - 06/2002
2Cetuximab (Erbitux)FDA Link
12/2004 - 05/2003
1Indicators and Reagents (Reagents)IBA
01/2021
1Epoxy Compounds (Epoxides)IBA
01/2019
1O-GlcNAc transferaseIBA
01/2019
1Anti-Bacterial Agents (Antibiotics)IBA
01/2018
1AngiopoietinsIBA
10/2016
1AminesIBA
03/2016
1DNA AdductsIBA
03/2016
1QuinoxalinesIBA
03/2016
1MutagensIBA
03/2016
1Fluorescent Dyes (Fluorescent Probes)IBA
10/2015
1pHLIP proteinIBA
10/2015
1Transcription Factors (Transcription Factor)IBA
05/2015
1Annexin A5IBA
05/2015
1Antineoplastic Agents (Antineoplastics)IBA
08/2014
1Sorafenib (BAY 43-9006)FDA Link
08/2014
1Peptide Initiation Factors (Initiation Factor)IBA
06/2014
1Phosphotransferases (Kinase)IBA
06/2014
1Inositol (Myoinositol)IBA
06/2014
1Kazal Pancreatic Trypsin InhibitorIBA
04/2014
1Peptide Hydrolases (Proteases)FDA Link
04/2014
1Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA
04/2014

Therapy/Procedure

38Therapeutics
01/2022 - 07/2002
6Pancreatectomy
03/2016 - 09/2011
5Drug Therapy (Chemotherapy)
01/2022 - 07/2002
4Neoadjuvant Therapy
01/2022 - 08/2008
3Autologous Transplantation
07/2014 - 04/2012
3Injections
09/2010 - 09/2007
3Cholecystectomy
04/2009 - 11/2005
2Radiotherapy
01/2011 - 07/2010
2Lymph Node Excision (Lymph Node Dissection)
01/2011 - 01/2010
2Pancreaticoduodenectomy
03/2010 - 04/2008
2Length of Stay
05/2007 - 01/2003
1Adjuvant Chemoradiotherapy
05/2015